271 hot topic(s) found with the query "Precision public health"
Population Screening for Hereditary Hemochromatosis
Video Webinar, UNC Precision Public Health Network,
(Posted: Mar 20, 2024 7AM)
From the website: " Current data suggest that 1 in 300 non-Hispanic White individuals in the United States carry a genetic variation in the HFE gene (C282Y homozygosity) that accounts for most cases of hereditary hemochromatosis (HH). This variation can lead to iron overload and life-threatening complications, such as severe liver disease. However, complications are preventable with early diagnosis and periodic phlebotomies to remove excess iron from the body. In this CDC webinar, speakers discussed how knowledge about HH has evolved since the discovery of the HFE gene in 1997, current opportunities for clinical and public health action to prevent disease, and future research priorities to advance case detection and reduce clinical complications from HH. "
Training Institute for Dissemination and Implementation Research in Genomics and Precision Public Health (TIDR-GPPH)
UNC Precision Public Health Network, March 2024
(Posted: Mar 20, 2024 7AM)
From the website: "This facilitated course is intended to provide participants with a thorough grounding in conducting dissemination and implementation (D&I) research with a specific focus on genomics and precision public health.is. TIDIR-GPPH will be a hybrid course including training through open access Training Institute for Dissemination and Implementation Research in Cancer (TIDIRC) with assigned reading material and office hours and a 2-day in-person event. Faculty and guest lecturers consist of leading experts in D&I theories, models, and frameworks; intervention fidelity and adaptation; stakeholder engagement and partnership for D&I; research methods and study designs for D&I; and measures and outcomes for D&I. "
Next Generation Public Health Genomics: A Call to Assess the Equitable Implementation, Population Health Impact, and Sustainability of Precision Public Health Applications
MC Roberts et al, Public Health Genomics, December 22, 2023
(Posted: Dec 22, 2023 10AM)
From the article: "The field of Public Health Genomics recently celebrated its twenty-fifth anniversary. Defined by the CDC as responsible and effective translation of genome-based knowledge and technologies for the benefit of population health, public health genomics applications have expanded beyond newborn screening to other applications poised to improve public health. Yet despite the promise and potential for public health genomics, the
population health impact and sustainability of public health genomics applications has yet to be fully measured and achieved. Further access to public health genomics applications has been lower among underrepresented racial and ethnic communities, rural communities, and groups with lower education and income, deepening concerns that the field could exacerbate rather than redress health inequities. "
The transition from genomics to phenomics in personalized population health.
James T Yurkovich et al. Nat Rev Genet 2023 12
(Posted: Dec 14, 2023 8AM)
From the abstract: "Here, we review ongoing large-scale genomics and longitudinal phenomics efforts and the powerful insights they provide into wellness. We describe our vision for the transformation of the current health care from disease-oriented to data-driven, wellness-oriented and personalized population health. "
Extending an Antiracism Lens to the Implementation of Precision Public Health Interventions.
Caitlin G Allen et al. Am J Public Health 2023 8 e1-e9
(Posted: Sep 06, 2023 9AM)
From the abstract: Growing concerns underscore the potential for precision-based approaches to exacerbate health disparities by relying on biased data inputs and recapitulating existing access inequities. To achieve its full potential, precision public health must focus on addressing social and structural drivers of health and prominently incorporate equity-related concerns, particularly with respect to race and ethnicity. In this article, we discuss how an antiracism lens could be applied to reduce health disparities and health inequities through equity-informed research, implementation, and evaluation of precision public health interventions."
Transdisciplinary Conference for Future Leaders in Precision Public Health, November 9, 2023
UNC Chapel Hill, Virtual Meeting, November 9, 2023
(Posted: Aug 22, 2023 10AM)
From the website: "We kicked off the Precision Public Health Network with our first transdisciplinary conference in 2021. We will build on the momentum from our first conference at our 2023 conference with the theme “Applying Implementation Science to Precision Public Health.” We will host a full day conference on Thursday, November 9 with expert speakers, breakout networking session, and a virtual poster session. A follow-up workshop will be held on Thursday, November 16 to discuss priority setting for the field. Register today. "
Get up to Speed on the Latest Developments in the Field! Register for the ORISE Current Issues in Genomics and Precision Public Health Online Training Event, September 7–8, 2023.
W White et al, CDC Blog Post, August 9, 2023
(Posted: Aug 09, 2023 11AM)
Advances in genomics, data science, machine learning, and artificial intelligence are transforming practice. Next generation public health and medical workforces need to understand these developments and how they can be used to benefit population health. Recognizing this challenge, Oak Ridge Institute for Science and Education (ORISE) is partnering with the Office of Genomics and Precision Public Health at the Centers for Disease Control and Prevention (CDC) to offer a free 2-day in-person training event covering the latest developments in these fields: Current Issues in Genomics and Precision Public Health – Using Genomics and Big Data to Improve Population Health and Reduce Health Inequities.
Genomics and Precision Public Health Issues Enrichment Event
Oak Ridge Institute for Science Education Enrichment Event, Atlanta, Georgia, September 7-8, 2023
(Posted: Jul 17, 2023 8AM)
In the past decade, genomics, and precision health approaches such as big data science and machine learning have emerged as important tools for public health. Those entering the public health and medical workforces must keep pace with these evolving fields to maximize the benefit to public health. Recognizing this need, ORISE is partnering with the Office of Genomics and Precision Public Health at the Centers for Disease Control and Prevention to offer a two-day in-person enrichment event covering the latest developments in these fields.
We Screen Newborns Don’t We? Progress in DNA-based Population Screening
Video presentations, CDC and Precision Public Health Network webinar, May 18, 2023
(Posted: Jun 06, 2023 8AM)
As part of 2023 Public Health Genetics and Genomics week, presenters in this webinar review the concept of population genomic screening for rare diseases beyond the newborn period, share research progress made in the last decade, and discuss the path forward to prepare the medical and public health communities for population-based genomic screening.
Increasing Use and Impact of Family Health History in Medically Underserved Populations: Work in Progress
G Wood et al, CDC Blog Post, December 20, 2022
(Posted: Dec 30, 2022 0PM)
Despite years of public health efforts, family health history remains underutilized in clinical care, especially among people who are medically underserved. To address these issues, CDC’s Office of Genomics and Precision Public Health hosted a webinar on November 14, 2022, in conjunction with National Family Health History Day (Thanksgiving). The speakers called for better informed, systematic, and tailored efforts to address inequities in clinical use of FHH
Public Health Genomics at the Centers for Disease Control and Prevention: Happy 25th Anniversary!
MJ Khoury, CDC Blog Post. December 12, 2022
(Posted: Dec 13, 2022 8AM)
In 1997, in response to the Human Genome Project, the CDC formed the Office of Genetics and Disease Prevention, now called the Office of Genomics and Precision Public Health (OGPPH). This was the beginning of the public health genomics movement in the United States and around the world. Our office continues to serve CDC programs, other federal agencies, state health departments, and other external partners by identifying, evaluating, and implementing evidence-based genomics applications to prevent and control the country’s leading chronic, infectious, environmental, and occupational diseases.
Data science and health economics in precision public health
MA Talias et al, Frontiers in Public Health, December, 2022
(Posted: Dec 07, 2022 8AM)
Theory, methods, and models from AI and data science are already changing the public health landscape in community settings and have shown promising results in multiple applications in public health, including geocoding health data, digital public health, predictive modeling and decision support, and mobile health. Overall, Precision Public Health utilizes tools and methods to extract health and non-health data at different levels of granularity, harmonize and integrate information about populations and communities to tailor cost-effective interventions for specific population groups, improving people's health.
Priorities for successful use of artificial intelligence by public health organizations: a literature review.
Fisher Stacey et al. BMC public health 2022 11 (1) 2146
(Posted: Nov 29, 2022 10AM)
Six key priorities for successful use of AI technologies by public health organizations are discussed: 1) Contemporary data governance; 2) Investment in modernized data and analytic infrastructure and procedures; 3) Addressing the skills gap in the workforce; 4) Development of strategic collaborative partnerships; 5) Use of good AI practices for transparency and reproducibility, and; 6) Explicit consideration of equity and bias.
Real-world data for precision public health of noncommunicable diseases: a scoping review.
Canfell Oliver J et al. BMC public health 2022 11 (1) 2166
(Posted: Nov 29, 2022 9AM)
Precision public health uses routinely collected real-world data on determinants of health (social, environmental, behavioural, biomedical and commercial) to inform precision decision-making, interventions and policy based on social position, equity and disease risk, and continuously monitors outcomes – the right intervention for the right population at the right time. This scoping review aims to identify global exemplars of precision public health and the data sources and methods of their aggregation/application to NCD prevention.
EDITORIAL: DNA-based Population Screening for Precision Public Health
LV Milko et al, Frontiers in Genetics, October 14, 2022
(Posted: Oct 15, 2022 7AM)
Rapid advances, increasing availability, decreasing costs of sequencing technologies, computational pipelines for variant interpretation, and training of clinical personnel, are accelerating the integration of genomic sequencing into routine health care. Although genomic sequencing has demonstrated utility as an indication-based diagnostic tool for certain diseases, the full potential of DNA sequencing as a non-diagnostic tool for population-level screening is not yet realized. We hope our readers find the collection of papers herein useful in advancing the dialogue on DNA-based population screening towards a new era of precision public health.
Intelligent risk prediction in public health using wearable device data
MM Raza et al, NPJ Digital Medicine, October 13, 2022
(Posted: Oct 13, 2022 6AM)
A recent study found that machine learning can predict the risk of COVID-19 infection, by combining biometric data from wearable devices like Fitbit, with electronic symptom surveys. In doing so, they aim to increase the efficiency of test allocation when tracking disease spread in resource-limited settings. But the implications of technology that applies data from wearables stretch far beyond infection monitoring into healthcare delivery and research. The adoption and implementation of this type of technology will depend on regulation, impact on patient outcomes, and cost savings.
From All of Us Research to All of Us in the Real World
CDC September 29 webinar, 1-hour video
(Posted: Oct 06, 2022 3PM)
Through a Data Use Agreement with the All of Us Research Program, scientists at the Centers for Disease Control and Prevention can now register to access and analyze All of Us Research Program Data through a cloud platform. This webinar reviewed the All of Us Research Program study design and current status, discussed its potential for providing important population data to inform implementation of disease prevention and to reduce health disparities and provided a training session for scientists interested in accessing and analyzing All of Us Data.
Precision public health must be at the centre of modern healthcare.
Prior David et al. BMJ (Clinical research ed.) 2022 8 o2119
(Posted: Sep 02, 2022 8AM)
The health of the population—what we now call public health—has been at the center of great religions and civilizations for thousands of years. As we reflect on the lessons of covid-19, genomics, and artificial intelligence, digital technology may help us to put health security and prevention of illness at the center of the health system. This is an extraordinary opportunity, but it requires a fundamental reassessment of how we deliver healthcare.
Calling on All of Us Public Health Scientists
MJ Khoury et al, CDC Blog Post, July 22, 2022
(Posted: Jul 23, 2022 8AM)
Scientists at the Centers for Disease Control and Prevention and elsewhere can now access and analyze data from the National Institutes of Health’s All of Us Research Program. In this post, we briefly explore three attributes of All of Us data that make them uniquely beneficial for public health scientists and other researchers interested in population health.
From All of Us Research to All of Us in the Real World: Using the All of Us Research Program Data to Improve Population Health
CDC Webinar, September 29, 2022
(Posted: Jul 07, 2022 1PM)
Through a Data Use Agreement with the All of Us Research Program, scientists at the Centers for Disease Control and Prevention can now register to access and analyze All of Us Research Program Data through a cloud platform. In this seminar we will: 1) Review the All of Us Research Program study design and current status, 2) Discuss its potential for providing important population data to inform implementation of disease prevention and to reduce health disparities and 3) Provide a hands-on training session for scientists interested in accessing and analyzing All of Us Data.
Approaches to Ethical Deliberation in Precision Public Health
CDC and Precision Public Health Network, July 27 webinar
(Posted: May 28, 2022 11AM)
There will be wide-ranging ethical implications as genomics shifts from within the medical paradigm to population-level programs. This talk will discuss how bioethics scholarship should approach issues related to the use of genetics and genomics in precision public health and the appropriate implementation of these technologies.
Using a Participatory Approach to Develop Research Priorities for Future Leaders in Cancer-Related Precision Public Health
MC Roberts et al, Frontiers in Genetics, May 2022
(Posted: May 26, 2022 7AM)
We held an interactive workshop during a virtual conference bringing together early-career researchers across public health disciplines to identify research priorities in precision public health. The workshop participants discussed and voted to identify three priority areas for future research and capacity building including 1) enhancing equity and access to precision public health research and resources, 2) improving tools and metrics for evaluation and 3) applying principles of implementation science to support sustainable practices.
DNA-based Population Screening for Precision Public Health
Milkow L, Khoury MJ (eds), Special Topic, Frontiers in Genetics, May 2022
(Posted: May 26, 2022 6AM)
DNA-based population screening to detect an individual's underlying predisposition to serious genetic conditions and improve health outcomes through risk assessment, early detection, and disease prevention, and timely treatment could accelerate the practice of precision public health. However, ascertainment of otherwise apparently healthy individuals with underlying genetic risk will necessitate a departure from the traditional model of familial or personal risk-based genetic testing in speciality settings to a population-based model of screening in primary care or community settings.
Host Genomics and COVID-19: Implications for Clinical and Public Health Practice
CDC Precision Public Health Webinar, October 6, 2022
(Posted: May 25, 2022 11AM)
This seminar will review our emerging knowledge of the role of host genomic factors in the susceptibility and outcomes of COVID-19 infection, response to vaccines and treatments as well as long-term sequels of the disease. Our speakers will discuss implications of such knowledge for clinical and public health practice and how this information could be used in the control of the pandemic, and more generally in the control of infectious diseases.
Colliding with Collider Bias: Implications for Precision Public Health
D Rasooly et al, CDC Blog Post, May 9, 2022
(Posted: May 09, 2022 11AM)
Large-scale genomic studies have uncovered thousands of statistical associations between genetic variants and health outcomes, transforming our understanding of the genetic determinants of human diseases. Nevertheless, study sample selection and attrition over time can bias associations between variables, generating potentially biased estimates for genetic associations. This bias can be magnified in the case of studying phenotypic associations with polygenic risk scores in large scale cohort studies of unrepresentative or highly selected populations, such as the UK biobank, and potentially in the newly launched All of Us Research Program cohort study.
COVID-19 GPH: tracking the contribution of genomics and precision health to the COVID-19 pandemic response
W Yu et al, BMC Infectious Diseases, April 25, 2022
(Posted: Apr 25, 2022 8AM)
To quantify and track the ongoing contributions of genomics and precision health to the COVID-19 response, the Office of Genomics and Precision Public Health at the Centers for Disease Control and Prevention created the COVID-19 Genomics and Precision Health database (COVID-19 GPH), an open access knowledge management system and publications database that is continuously updated through machine learning and manual curation.
This unique knowledge management database makes it easier to explore, describe, and track how the pandemic response is accelerating the applications of genomics and precision health technologies.
Center for Forecasting and Outbreak Analytics
CDC, April 2022
(Posted: Apr 20, 2022 9AM)
The CDC Center for Forecasting and Outbreak Analytics (CFA) was created to improve the nation’s ability to prepare for and respond to infectious disease threats using data, modeling, and analytics. CFA will produce models and forecasts to characterize the state of an outbreak and its course, inform public health decision makers on potential consequences of deploying control measures, and support innovation to continuously improve the science of outbreak analytics and modeling.
Geospatial Determinants of Health
ATSDR, 2022
(Posted: Apr 06, 2022 8AM)
Geospatial science, geographic information systems (GIS), and cartographic visualization provide important concepts, methods, and tools equipping public health scientists to examine, characterize, and analyze the important relationship between our health and the places of our lives. As part of its work, GRASP has proposed and is shaping a framework, the Geospatial Determinants of Health (GDOH), that articulates the many and varied geospatial drivers that influence disease prevalence and promote health. The GDOH are at work in multiple environments where we experience health, including the natural environment, built environment, population connectivity environment, social and behavioral environment, and health policy environment.
Precision Public Health in Action: Enhancing models to predict risk of adverse treatment outcomes in people with hemophilia
CJ Bean et al, CDC Blog Post, March 29, 2022
(Posted: Mar 30, 2022 7AM)
CDC investigators have developed a genetic inhibitor risk prediction tool hat is based on information about the genetic variant causing a person’s hemophilia, genetic variation in the HLA region and in immune response genes. However, this tool has thus far been evaluated in a relatively small number of people with hemophilia. In this newly funded project, investigators will evaluate the performance of the existing inhibitor risk prediction tool in a diverse patient population. Previous studies of the prediction tool were conducted in populations of non-Hispanic, White persons with hemophilia.
Applied Research in Public Health Genomics at the Centers for Disease Control and Prevention
CDC Mini Symposium, May 26, 2022
(Posted: Mar 29, 2022 7AM)
The CDC Office of Genomics and Precision Public Health will hold a mini symposium during national public health genetics to highlight current and future applied research in human genomics and public health at the CDC. This mini symposium will identify opportunities and challenges for using human genomics in public health programs. Speakers will review individual projects and identify cross cutting needs and opportunities for integrating human genomics into public health, using a health equity lens.
Advancing Implementation Science in Precision Public Health: Ensuring Health Equity and Balancing Evolution and Sustainment
Precision Public Health Network webinar, April 27, 2022
(Posted: Mar 22, 2022 7AM)
The rapid development of advances in biomedical research creates levers to improve precision health and health care. However, without complementary attention to a robust agenda on implementation science, we risk replicating the “bench” to “bookshelf” pathway for scientific discoveries. Dr David Chambers will discuss challenges and opportunities, assumptions and ongoing activities toward advancing implementation science in the context of dynamic systems, an evolving evidence base and a desire to sustain effective and equitable health interventions over time.
Using Pharmacogenetics to Enhance Tuberculosis (TB) Treatment
M Moore et al, CDC Blog Post, February 22, 2022
(Posted: Feb 23, 2022 7AM)
A new CDC project provides an unprecedented opportunity to develop a tailored approach, by leveraging existing information collected in the international phase 3 clinical trial, to identify specific dosage recommendations of TB drugs for populations, which can improve TB treatment across all patient groups. Researchers will utilize precision public health techniques to assess treatment outcomes for TB treatment regimens, which may lead to improvements in the prevention and treatment of TB disease.
Future Forecast: Imagining Social and Behavioral Research for Genomic Translation
Colleen McBride, Precision Public Health Network lecture, March 1, 2022
(Posted: Feb 15, 2022 11AM)
The goal of the Precision Public Health Network is to connect future public health clinicians, researchers, and policymakers exploring precision approaches to improving population health. The PPH Network connects aspiring precision public health leaders through sponsoring working groups for research collaboration, hosting lectures with experts in the field, and organizing the Transdisciplinary Conference for Future Leaders in Precision Public Health
Precision Public Health in Action: New CDC Pilot Projects Integrating Human Genomics into Public Health Surveillance and Applied Research
M Clyne et al, CDC Blog Post, February 14, 2022
(Posted: Feb 15, 2022 7AM)
Six CDC projects were selected for funding in 2022 and 2023. They cover a wide range of topics, including: Assessing the impact of genetics in the control of two infectious diseases (Tuberculosis and Ebola), enhancing the reporting of gene/genome sequencing in newborn screening programs, examining the role of medications and genetics in the National Birth Defects Prevention Study (NBDPS), establishing population-based, ethnicity-specific allele frequencies for pharmacogenomic traits of public health importance using the National Health and Nutrition Examination Survey (NHANES), and enhancing the evaluation of genetic risk prediction models for inhibitor development among people with hemophilia in different populations.
From Precision Medicine to Precision Public Health: The Dialogue Continues
MJ Khoury et al, January 25, 2022
(Posted: Jan 26, 2022 8AM)
In this post, we focus on two distinct components of precision public health: its role in reaping the population health benefits of precision medicine, and its use of new tools and technologies to refine essential functions of population health assessment, policy development, and assurance. As public health is attempting to improve on its data collection, analysis, dissemination and sharing through the data modernization initiative, we are seeing an evolution in our ability to meld new approaches with old approaches. Far from being blindsided by the data opportunities, next generation medicine and public health will continue to evolve by applying new tools and technologies to improve health for individuals and populations.
Is precision public health the future — or a contradiction?
C Arnold, Nature, January 4, 2022
(Posted: Jan 04, 2022 7AM)
Some public-health researchers are embracing data and technology to target small groups with precise health interventions. Others fear that these tactics could fail millions. Whether or not researchers see a conflict between public health’s fundamental mission and its new ‘precision’ arm, both sides agree on one thing: public health will continue to be of utmost importance in the coming decades. The goal is to improve the health of the whole population, using all the tools that we have, whether we call them precision public health or not.
A Mini-Symposium: Implementing Precision and Equitable Public Health in Cascade Testing for Genetic Disorders
CDC event, Feb 10, 2022
(Posted: Dec 13, 2021 2PM)
While there are Tier 1 evidence-based guidelines supporting cascade testing for hereditary breast and ovarian cancer syndrome, Lynch syndrome, familial hypercholesterolemia, and other genetic disorders, the focus is on whether such testing should be done, rather than how to implement cascade testing in practice, both effectively and equitably. Before the full potential health impact of cascade genetic testing can be reached, we must develop a much stronger understanding of which component procedures and practices work best, and then leverage those good practices toward delivering precision public health. This two-hour virtual mini-symposium will explore several efforts to better understand what works well in programs relevant to cascade testing for genetic disorders.
From Public Health Genomics to Precision Public Health: On to the Next Generation!
Muin J. Khoury Video Presentation, at the Transdisciplinary Conference for Future Leaders in Precision Public Health. Posted on November 11, 2021
(Posted: Nov 12, 2021 11AM)
In this presentation Dr Khoury discusses the evolution of the field of public health genomics over the past 25 years into precision medicine and precision public health, which involves applications of genomics , big data and predictive analytics to population health. He also describes ongoing applications of precision public health to the COVID-19 response.
Transdisciplinary Conference for Future Leaders in Precision Public Health
Speakers Slide Presentations, November 2021
(Posted: Nov 12, 2021 7AM)
This virtual event held in October 2021 connected future research leaders around the world interested in the role of genetics and precision health in the promotion of public health. The speakers provided opportunities for early career investigators to discuss new developments in precision public health with leading experts in the field. Attendees heard from expert epidemiologists, behavioral scientists, statisticians, and global public health leaders about topics such as health equity in genetic epidemiology, genetic risk communication in cancer care, and biostatistics and modeling.
Precision Public Health in the Pandemic: Using MicrobeTrace to Track COVID-19 - Introduction
Slides, May 26, 2021 - CDC Webinar
(Posted: Aug 14, 2021 8AM)
The Complementarity of Public Health and Medicine — Achieving “the Highest Attainable Standard of Health”
DJ Hunter, NEJM, August 5, 2021
(Posted: Aug 04, 2021 5PM)
Preventive medicine can be practiced with individual patients in a consulting room or through organized activities such as vaccine outreach, community blood-pressure screening, or health education. Future “big data” analyses may both provide insights into population health as well as permitting more personalized medical care.
Digital Twins: From Personalised Medicine to Precision Public Health
MNK Boulos, MPI J Pers Medicine, July 2021
(Posted: Jul 30, 2021 7AM)
A digital twin is a virtual model of a physical entity, with dynamic, bi-directional links between the physical entity and its corresponding twin in the digital domain. Digital twins are increasingly used today in different industry sectors. Applied to medicine and public health, digital twin technology can drive a much-needed radical transformation of traditional electronic health/medical records (focusing on individuals) and their aggregates (covering populations) to make them ready for a new era of precision (and accuracy) medicine and public health. Digital twins enable learning and discovering new knowledge, new hypothesis generation and testing, and in silico experiments and comparisons
Mendelian Randomization: A Precision Public Health Tool for the COVID-19 Response
E Drzymalla et al, CDC Blog, July 20, 2021
(Posted: Jul 21, 2021 7AM)
In the early days of the COVID-19 pandemic, when little was known about the natural history of the disease, predicting the course of the pandemic was of premier importance for treating sick patients and redoubling efforts to protect those at highest risk of adverse outcomes. To address this need, investigators used a study design that is rooted in human genetics, Mendelian randomization, an approach that has been used to identify important modifiable risk factors for common chronic diseases.
DNA-based Population Screening for Precision Public Health
Call for papers, Frontiers in Genetics, July 2021
(Posted: Jul 04, 2021 8AM)
Advancement and increasing availability of sequencing technologies, computational pipelines for variant interpretation, and training of clinical personnel, coupled with decreasing sequencing costs, have nudged genomic sequencing ever closer to the practice of routine health care. While genetic testing has demonstrated utility as an indication-based diagnostic tool for certain diseases, the full potential of genomic sequencing as a non-diagnostic tool for population-level screening is not yet realized.
Pharmacogenomics: From Precision Medicine to Precision Public Health
CDC webinar, October 7, 2021
(Posted: Jun 29, 2021 8AM)
Advances in pharmacogenomics continue to occur at a rapid pace and promise a new era of personalized interventions for disease treatment and prevention. In this seminar, we explore the evolution of the field from basic science discoveries to clinical and population health applications.
What should be the public health priorities in genomics and precision medicine in the next decade?
M Khoury et al, CDC Blog Post, June 9, 2021
(Posted: Jun 10, 2021 10AM)
The CDC Office of Genomics and Precision Public Health is undergoing strategic planning to identify major opportunities for impact of public health action in human genomics and precision medicine in the next decade. As part of this process, we interviewed nine persons external to CDC from diverse backgrounds and organizations that represent the leading edge of human genomics in health practice.
Advancing precision public health using human genomics: examples from the field and future research opportunities
MC Roberts et al, Genome Medicine, June 1, 2021
(Posted: Jun 02, 2021 9AM)
We provide examples of promising opportunities and current applications of genomics research within precision public health and outline future directions within five major domains of public health: biostatistics, environmental health, epidemiology, health policy and health services, and social and behavioral science.
Convergence of Precision Medicine and Public Health Into Precision Public Health: Toward a Big Data Perspective.
Velmovitsky Pedro Elkind et al. Frontiers in public health 2021 9561873
(Posted: Apr 27, 2021 9AM)
With the coming of Big Data, the fields of precision medicine and public health are converging into precision public health, the study of biological and genetic factors supported by large amounts of population data. In this paper, we explore through a comprehensive review the data types and use cases found in precision medicine and public health.
The impact of genomics on precision public health: beyond the pandemic.
Khoury Muin J et al. Genome medicine 2021 4 (1) 67
(Posted: Apr 25, 2021 7AM)
As the COVID-19 pandemic clearly shows, we need the tools of genomics more than ever before in the fight against infectious diseases. Beyond fighting outbreaks, genomics will become an essential component of public health in the twenty-first century for communicable and noncommunicable diseases.
Leveraging Advances in Remote Geospatial Technologies to Inform Precision Environmental Health Decisions - A Workshop
NASEM Workshop, April 14, 2021
(Posted: Apr 05, 2021 3PM)
This workshop will explore how advances in the resolution of geospatial technologies could inform “precision environmental health”—targeted public health interventions that reach the right populations at the right time. Workshop sessions will also focus on the use of geospatial technologies to address environmental justice issues, and to direct responses to environmental disasters.
Data-Driven Surveillance: Effective Collection, Integration, and Interpretation of Data to Support Decision Making.
Dórea Fernanda C et al. Frontiers in veterinary science 2021 8633977
(Posted: Apr 02, 2021 10AM)
An increasing number of new data sources, including many not originally collected for health purposes, are now being used for epidemiological inference and contextualization. Combining evidence from multiple data sources presents significant challenges, but discussions around this subject often confuse issues of data access and privacy, with the actual technical challenges of data integration and interoperability.
Applications of Digital Tools for Precision Public Health in the COVID-19 Era: Where Are We?
M Khoury et al, CDC Blog, March 29, 2021
(Posted: Mar 31, 2021 8AM)
Two scoping reviews provide valuable insights into the current limitations of digital health technologies in public health. Significant challenges remain in adoption, scale-up, and integration into healthcare systems and public health programs. Other considerations include equity issues in deployment of such technologies among disproportionately affected groups.
Precision Public Health in the Pandemic- Using MicrobeTrace to Track COVID-19
CDC May 26 webinar
(Posted: Mar 21, 2021 7AM)
MicrobeTrace is a secure, local, and user-friendly data visualization tool developed by the CDC, initially for HIV cluster detection and response, that has been rapidly retooled and adopted for the COVID-19 response. MicrobeTrace allows users to map transmission networks based on person-to-person contacts, pathogen-to-pathogen genetic distance, or person-to-place exposures. This webinar will provide an overview of how MicrobeTrace can be used in the COVID-19 response.
Digital public health surveillance: a systematic scoping review
Z Shakeri et al, NPJ Digital Medicine, March 3, 2021
(Posted: Mar 04, 2021 7AM)
The ubiquitous and openly accessible information produced by the public on the Internet has sparked an increasing interest in developing digital public health surveillance (DPHS) systems. We conducted a systematic scoping review to consolidate and characterize the existing research on DPHS and identify areas for further research.
CDC Resources in Genomics and Precision Health to Enhance Public Health Impact of New Technologies
CDC Webinar, March 25,2021
(Posted: Feb 27, 2021 7AM)
Advances in genomics and precision health are ushering a new era of precision medicine and precision public health. The pace of scientific discoveries is accelerating and the applications in research, clinical, and public health practice are multiplying. For just about anyone – researchers, practitioners and the general public alike – staying abreast of the latest news and publications is a daunting task.
Is precision medicine relevant in the age of COVID-19?
Zhou Amy et al. Genetics in medicine : official journal of the American College of Medical Genetics 2021 Jan
(Posted: Jan 16, 2021 3PM)
This commentary argues that precision medicine and precision public health are relevant for addressing COVID-19 but caution against too great an emphasis on this approach. “Precise” interventions need to complement efforts to strengthen public health infrastructure and address fundamental social, economic, and environmental causes of illness.
Mapping routine measles vaccination in low- and middle-income countries
Local Burden of Disease, Nature, December 2020
(Posted: Dec 20, 2020 11AM)
We generated annual estimates of routine first-dose measles-containing vaccine coverage at 5 × 5-km2 pixel and second administrative levels from 2000 to 2019 in 101 low and middle income countries, quantified geographical inequality and assessed vaccination status by geographical remoteness.
PLACES: Local Data for Better Health
CDC, December 2020
(Posted: Dec 11, 2020 8AM)
The PLACES Project is a collaboration between CDC, the Robert Wood Johnson Foundation, and the CDC Foundation. PLACES allows counties, places, and local health departments regardless of population size and urban-rural status to better understand the burden and distribution of health outcomes in their jurisdictions and assist them in planning interventions.
Transparency, trust, and community welfare: towards a precision public health ethics framework for the genomics era
ET Juengst et al, Genome Medicine, November 20, 2020
(Posted: Nov 23, 2020 4PM)
Infectious disease control is experiencing a paradigm shift, as pathogen sequencing technologies and digital applications are increasingly implemented. A new ethical framework should ensure that the benefit of precision public health interventions is not outweighed by risks to individuals and vulnerable segments of the population. The ethical framework combines standard precepts from public health ethics with emerging ethics principles from precision medicine.
The intersection of genomics and big data with public health: Opportunities for precision public health.
Khoury Muin J et al. PLoS medicine 2020 Oct 17(10) e1003373
(Posted: Oct 30, 2020 10AM)
Precision public health (PPH) has emerged as a response to the increasing availability of genomics, biobanks, and other sources of big data in healthcare and public health. ?The field has evolved starting with genomics to include multiple practical applications such as pathogen genomics that address population health. ?PPH can expand understanding of health disparities, advance strategic public health science, and demonstrate the need for innovation and workforce development.
Reimagining Public Health in the Aftermath of a Pandemic.
Brownson Ross C et al. American journal of public health 2020 11 (11) 1605-1610
(Posted: Oct 22, 2020 8AM)
A reinvented public health system will depend highly on leadership and political will, rethinking how we categorize and address population-level risk, employing 21st-century data sciences, and applying new communication skills.
Data Are Not Enough to Reimagine Public Health.
Chiolero Arnaud et al. American journal of public health 2020 Nov (11) 1614
(Posted: Oct 22, 2020 8AM)
Data, however, will not be enough. Improving our public health surveillance systems requires policymakers and health data scientists to work together; they have to develop a common culture and agree on surveillance goals. Policymakers must be trained in surveillance principles and methods in this age of data science.
A Strong Start: Enhancing Newborn Screening for Precision Public Health
D Jones et al, CDC Blog Post, October 13, 2020
(Posted: Oct 15, 2020 7AM)
Genome sequencing can help enhance newborn screening programs by providing more information beyond traditional biochemical and other tests. Not all states have the expertise needed to interpret results, A recent pilot project in Utah showed how an existing open-source data standard can successfully be used to transmit newborn screening genomic data.
Global maps of travel time to healthcare facilities
DJ Weiss et al, Nature Medicine, September 28, 2020
(Posted: Sep 29, 2020 8AM)
Leveraging the geographically variable strengths of our facility datasets, we characterize travel time to healthcare facilities in unprecedented detail. We produce maps of travel time with and without access to motorized transport, thus characterizing travel time to healthcare for populations distributed across the wealth spectrum.
Harnessing Novel Data Sources and Technologies for the Study of Social Determinants of Health
NHLBI Event, September 29 - 30, 2020
(Posted: Sep 04, 2020 9AM)
Observing the health of individuals in real time, such as through mobile monitoring, may provide researchers with better data and improve health outcomes. These technologies and data sources can enhance the study of social determinants of health to better address health disparities by race, ethnicity, gender, sexual orientation, and geography.
Digital public health and COVID-19
CJL Murray et al, Lancet Public Health, August 2020
(Posted: Aug 18, 2020 6AM)
We use the ongoing COVID-19 pandemic to explore some of the ways in which digital public health can transform the public health response. Through this exploration, we hope to highlight the broader potential for digital public health in making public health prevention, surveillance, and responses more effective across a wide range of challenges.
Precision Public Health as a Key Tool in the COVID-19 Response
SA Rasmussen et al, JAMA, August 12, 2020
(Posted: Aug 12, 2020 11AM)
The COVID-19 pandemic provides an opportunity for further evolution of the field of precision public health, as new tools and technologies begin to complement traditional medical and public health approaches to prevention and control. Despite challenges, at no time has precision public health been needed more than now.
COVID-19 Genomics and Precision Public Health Weekly Update
CDC, August 2020
(Posted: Aug 08, 2020 10AM)
Averting hunger in sub-Saharan Africa requires data and synthesis
J Porciello et al, Nature, August 5, 2020
(Posted: Aug 07, 2020 7AM)
As the United Nations warns of famine on a scale not seen in 50 years, researchers must help to build agile, inclusive data collection and analysis to inform agricultural policy.
COVID-19 and School Closures
JM Donohue et al, JAMA, July 29, 2020
(Posted: Jul 29, 2020 0PM)
A precision public health approach means having easy access to real-time data to evaluate the effectiveness of specific approaches and adjust accordingly. A precision public health approach also benefits from strong collaborations. School nurses, administrators, parents, and educators need to perceive data and experts interpreting these data as trustworthy.
From Precision Medicine to Precision Public Health: Beyond the Pandemic
MJ Khoury et al, CDC Blog Post, June 18, 2020
(Posted: Jun 21, 2020 3PM)
As the CDC Coronavirus Disease portal in genomics and precision health shows, an emerging display of scientific productivity is shifting the narrative from precision medicine to precision public health in response to the COVID-19 pandemic.
Social determinants of health, data science, and decision-making: Forging a transdisciplinary synthesis
S Galea et al, PLOS Medicine, June 2020
(Posted: Jun 18, 2020 2PM)
It is time to bring about a transdisciplinary synthesis of different streams. The social determinants of health represent an agenda for action to improve health that can be enhanced by a serious engagement with the role that data and technology are beginning to play in improving population health.
A precision public health approach to preventing the next COVID-19 surge: it’s time to talk about surveillance
M Matone blog, The Incidental Economist, May 2020
(Posted: Jun 01, 2020 1PM)
We propose a contrasting approach that includes a number of synchronous activities: An enhanced surveillance model featuring syndromic and participatory methods, prioritized testing for high-risk populations, and community-level quarantine protocols.
All Hands on Deck! Geospatial Mapping in Outbreaks
ATSDR, May 2020
(Posted: May 13, 2020 10AM)
To visualize the outbreak on the cruise ship, a 3-dimensional (3D) model of the cruise ship mapped rooms that had sick passengers to visualize the spatial relationships between the sick passengers and the locations of their staterooms. Without the 3D model of the cruise ship, investigators may not have identified potential important moments in the outbreak
Using Digital Technologies in Precision Public Health: COVID-19 and Beyond
MJ Khoury et al, CDC Blog, April 2020
(Posted: Apr 26, 2020 8AM)
With the global spread of COVID-19, there is a proliferation of scientific information and publications that use novel approaches such as genomics and precision health tools (e.g., big data, wearables, and digital devices) in surveillance and epidemiologic investigations. Could these new technologies provide added value to traditional approaches?
The impact of genomics on precision public health
Call for Papers, Genome Medicine, April 22, 2020
(Posted: Apr 23, 2020 8AM)
Human and pathogen genomics are at the leading edge of the application of new technologies to public health practice. Research efforts in this area are contributing to a new era of 'precision public health', an emerging multidisciplinary field that uses genomics, other big data and artificial intelligence to improve population health.
The Public Health Impact of COVID-19: Why Host Genomics?
MJ Khoury el al, CDC Blog, April 21, 2020
(Posted: Apr 22, 2020 0PM)
Ideally, scientific studies of COVID-19 risk factors for transmission and severity should include both viral and human genomes and the interaction of these two genomes, along with other traditional environmental, social and economic factors, and emerging types of big data. This is part of a precision public health response.
Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017
Nature Medicine, April 20, 2020
(Posted: Apr 21, 2020 10AM)
A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low- and middle-income countries from 2000 to 2017 and aggregate these to policy-relevant administrative units.
Aggregated mobility data could help fight COVID-19
CO Buckee et al, Science, April 10, 2020
(Posted: Apr 10, 2020 10AM)
Precision public health in action: "A map that examines the impact of social distancing messaging or policies on population mobility patterns, for example, will help county officials understand what kinds of messaging or policies are most effective."
Addressing Social Determinants of Health- Time for a Polysocial Risk Score
JF Figueroa et al, JAMA, April 3, 2020
(Posted: Apr 04, 2020 10AM)
The polygenic risk score model offers the field of social determinants of health a possible path forward. Developing an individualized “polysocial risk score” could help predict the risk that varying combinations of social conditions are related to specific health outcomes.
Manipulating the Human Microbiome for Precision Public Health: Prospects and Challenges
M Haile et al, CDC Blog, March 31, 2020
(Posted: Apr 02, 2020 3PM)
There are emerging and potential applications for manipulating the human microbiome for disease prevention and management. Progress in understanding how the human microbiome can be leveraged for public health is exemplified in recent CDC-funded studies.
In the Era of Public Health Emergencies, Interoperability Rules are a Beacon for More Precision in Public Health
P Braun, March 30, 2020
(Posted: Apr 02, 2020 3PM)
In the current wake of COVID-19, it is evident that the public health ecosystem needs to modernize how we gather, make sense of, and disseminate data from multiple sources. The health threats we face today spread wider and change faster than the data flows our traditional approaches were designed to accommodate.
Transforming Global Health with AI.
Mehta Mehul C et al. The New England journal of medicine 2020 Feb (9) 791-793
(Posted: Mar 03, 2020 8AM)
Artificial intelligence (AI) has the potential to revolutionize health and health care in LMICs by addressing the large knowledge and judgment gaps that make care delivery poor. AI utilizes machine-learning technology that analyzes and interprets large data sets, using powerful computing resources.
Coronavirus 2019-nCoV global cases by Johns Hopkins CSSE
Johns Hopkins University, February 2020
(Posted: Feb 08, 2020 10AM)
Precision public health in action: A data visualization tool to track the geographic spread of new coronavirus. Developed by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University
Introducing "Precision Health Promotion": The Convergence of Genomics, Health Education, and Lived Experience.
Terry Paul E et al. American journal of health promotion : AJHP 2020 Jan 890117120903129
(Posted: Feb 05, 2020 9AM)
Some voice concerns that the growth of PM emphasize the medical model for health with undue focus on individual rather than societal solutions. We introduce precision health promotion as "the personalized design of lived experiences that foster improved health and well-being for individuals within the context of their families, organizations and communities."
Quantification of Neighborhood-Level Social Determinants of Health in the Continental United States
M Kolak et al, JAMA Network Open, January 2020
(Posted: Feb 03, 2020 9AM)
In this cross-sectional study of 71?901 census tracts with approximately 312 million persons across the continental United States, multivariate social determinants of health measures were reduced to 4 indices reflecting advantage, isolation, opportunity, and mixed immigrant cohesion and accessibility and were clustered into 7 neighborhood typologies.
Scientific challenges for precision public health.
Kee Frank et al. Journal of epidemiology and community health 2020 Jan
(Posted: Jan 29, 2020 8AM)
The notion of 'precision' public health has been the subject of much debate, with recent articles coming to its defence following the publication of several papers questioning its value.Critics of precision public health raise the following problems and questionable assumptions: the inherent limits of prediction for individuals
FH as a Prototype for Precision Public Health
The FH Foundation, 2019 FH Global summit, day 2 highlights, January 2020
(Posted: Jan 22, 2020 9AM)
Dr. Muin Khoury kicked off Day 2 by discussing how FH sets the stage for precision public health for other inherited conditions. Khoury underscored the importance of data for more precisely developing and delivering public health programs to sub-populations:“Families live across states and healthcare systems. We can’t do this without precision.”
2019 FH Global Summit Presentation Slides
The FH Foundation, January 2020
(Posted: Jan 15, 2020 8AM)
The 7th annual FH Global Summit was held in Atlanta, Georgia from October 20-21 and focused on familial hypercholesterolemia as a prototype for precision public health. Over 280 interdisciplinary participants including experts in FH, genomics, precision medicine, as well as healthcare practitioners, individuals with FH and industry attended.
Precision Public Health Asia 2020 Meeting
Singapore, April 1-3, 2020
(Posted: Jan 12, 2020 2PM)
Precision Public Health Asia 2020 Conference (PPH Asia 2020) aims to bring together policymakers, academics, industry stakeholders and technology and public health professionals to explore how the tools of the Fourth Industrial Revolution can be brought to bear in public health to benefit both the developed and developing worlds.
Innovation should support societal responsibility for health
R Milne et al, BMJ Blog, January 2020
(Posted: Jan 07, 2020 8AM)
The popular emphasis on genomics and precision health technology being harnessed by individuals fails to consider how it can be used to improve social determinants of health.
Progress in Pathogen Genomics as a Prototype for Precision Public Health
MJ Khoury, CDC Blog Post, January 2, 2020
(Posted: Jan 04, 2020 2PM)
Rapid advances in pathogen genomics have ushered in a new era of “precision public health.” Next-generation sequencing is already enabling more effective investigations of outbreaks of foodborne illnesses, better-targeted tuberculosis control, and more timely and granular influenza surveillance.
Personalized public health: An implementation research agenda for the HIV response and beyond.
Geng Elvin H et al. PLoS medicine 2019 Dec (12) e1003020
(Posted: Jan 03, 2020 9AM)
The scientific trajectory in the HIV response has been a remarkable microcosm of the translational scientific process. Success in the HIV response depends on the effectiveness, efficiency, and quality of implementation. Bringing personalized public health into practice will require us to a genuine implementation science agenda.
Deep Green Diagnostics: Urban Green Space Analysis Using Deep Learning and Drone Images.
Moreno-Armendáriz Marco A et al. Sensors (Basel, Switzerland) 2019 Nov 19(23)
(Posted: Dec 11, 2019 9AM)
The main purpose is to provide health institutions with software capable of creating updated maps that indicate where these phenomena are presented, as this information could be very useful to guide public health goals in large cities. Our software is released as open source code, and data used for the experiments presented are also freely available.
Precision public health emerging as a discipline
JK COhen, Modern Healthcare, November 30, 2019
(Posted: Dec 02, 2019 8AM)
A new buzzword has crept into the health sciences lexicon: precision public health. By mixing the technical advancements of precision medicine with the goals of public health, practitioners they can improve health at the population level. A quick search on the PubMed for “precision public health” suggests the term is catching on, returning 75 articles since 2016.
Improving the geographical precision of rural chronic disease surveillance by using emergency claims data: a cross-sectional comparison of survey versus claims data in Sullivan County, New York.
Lee David C et al. BMJ open 2019 Nov 9(11) e033373
(Posted: Nov 26, 2019 8AM)
For select conditions, emergency claims data may be useful for tracking disease prevalence in rural areas and providing more geographically detailed estimates. For rural regions lacking robust health surveillance, emergency claims data can inform how to geographically target efforts to prevent chronic disease.
Precision Medicine and Precision Public Health in the Era of Pathogen Next-Generation Sequencing
R Leguia et al, J Infectious Dis, November 2019
(Posted: Nov 24, 2019 7AM)
We briefly discuss the history of NGS technologies and describe how the techniques developed during the past 40 years have impacted our understanding of infectious diseases. Beyond obvious clinical and public health applications, we also discuss the challenges that still remain within this rapidly evolving field.
Artificial intelligence for global health
A Hosny et al, Science, November 21, 2019
(Posted: Nov 22, 2019 8AM)
AI could play an important role in addressing global health care inequities at the individual patient, health system, and population levels. However, challenges in developing and implementing AI applications must be addressed ahead of widespread adoption and measurable impact.
In Precision Medicine, ‘We Need Dialogue Across Disciplines’
Boston University School of Public Health, November 2019
(Posted: Nov 20, 2019 9AM)
Precision medicine is often reduced to being all about genetics, but I think that’s a misread on how it was originally conceived. When I think about the promise of precision, it’s the ability to harness tools in a wide variety of research activities that will improve the way we deliver care in the clinical setting, and the way we think about population health.
Familial Hypercholesterolemia as a Prototype for Precision Public Health
MJ Khoury et al, CDC Blog, November 19, 2019
(Posted: Nov 20, 2019 9AM)
In the absence of population screening guidelines specific to FH, and in the midst of all people with cholesterol-related health problems, how do we find and treat persons with FH? One answer to this question may be precision public health. Precision public health leverages emerging data by time, place, and persons, coupled with machine learning methods.
